Question 1

Why is MOTS-c called an exercise mimetic?

Accepted Answer

MOTS-c activates AMPK and regulates glucose metabolism in skeletal muscle, reproducing some metabolic benefits of physical exercise.

Question 2

What makes MOTS-c unique among peptides?

Accepted Answer

MOTS-c is encoded by mitochondrial DNA rather than nuclear DNA, representing a novel form of mitochondrial-nuclear communication.

Question 3

Has MOTS-c been tested in humans?

Accepted Answer

Human clinical trials are very limited. Most evidence comes from preclinical mouse models.

What is MOTS-c - Peptide Encyclopedia