Question 1

Is Tesamorelin FDA-approved?

Accepted Answer

Yes, as Egrifta/Egrifta SV for HIV-associated lipodystrophy.

Question 2

How does Tesamorelin differ from Sermorelin?

Accepted Answer

Both are GHRH analogs, but Tesamorelin is the full 44-amino-acid GHRH with a stabilizing modification, giving it longer half-life (~26-38 min vs ~11 min) and greater potency.

Question 3

Why is bioavailability so low?

Accepted Answer

Like most peptides, tesamorelin undergoes enzymatic degradation after injection. The approved dose accounts for this with sufficiently high dosing.

What is Tesamorelin - Peptide Encyclopedia