Question 1

Why is kisspeptin important for fertility?

Accepted Answer

Kisspeptin is the master upstream regulator of GnRH neurons, triggering the entire reproductive hormone cascade.

Question 2

Why does continuous kisspeptin cause tachyphylaxis?

Accepted Answer

Continuous exposure causes KISS1R receptor desensitization, paradoxically suppressing hormones. Pulsed dosing is essential.

Question 3

Do effects differ between men and women?

Accepted Answer

Yes. Men show robust LH stimulation at all times, but in women the response depends on menstrual cycle phase, strongest in the preovulatory period.

What is Kisspeptin - Peptide Encyclopedia